For millions of people, osteoarthritis slowly breaks down the joints, bringing pain, swelling and stiffness that make free movement harder with time. It is largely a condition of age, with 73% of those living with it older than 55.

For years, the wear and tear that comes with aging and physical trauma was considered a major driver of the disease. A recent study published in Science, however, points to a metabolic disease that is also highly common among this demographic as a contributing factor in osteoarthritis progression.