A research team from the School of Public Health at the LKS Faculty of Medicine, the University of Hong Kong (HKUMed), has discovered that emerging omicron sublineages of SARS-CoV-2 use distinct biological strategies to spread and cause disease. Specifically, the XBB.1.5 and EG.5.1 variants are better adapted for respiratory spread and may pose a heightened risk of severe respiratory disease, while BA.2.86 and JN.1 tend to replicate more effectively in the intestines, potentially opening alternative transmission routes.